Vash travels to Inepril City where he is ambushed by a group of bounty hunters looking to cash in on his $60,000,000,000 dollar head. Once he has dispatched the hunters he find himself being hunted by the towns people as well. The mayor of the town has developed a scheme to save the city, and with the bounty money has can revive the power plant so that people will stop leaving the town and the city will be prosperous again.
The mayor has also hired the help of the Nebraska brothers, criminals who will stop at nothing to hunt down Vash but in the process my destroy the town. Now Vash will need to save the town as well as its people from their own bad decisions and will need to take the Nebraska brothers down.
Meryl and Milly show up to try to stop the town from causing any damage that the insurance company they work for may have to pay out too. I the process Meryl finally realizes that the goofy odd man in the red trench coat is the real Vash, and there is no doubt about it. Even though Vash does not wish to kill or hurt anyone, his skills are undoubtedly are exactly as the legend proclaims it is.